Toposar Drug Interactions

Mifepristone
Mifepristone may increase the level of Toposar in your bloodstream, increasing your risk for side effects. This interaction is more likely to be a concern when mifepristone is taken on an ongoing basis, as opposed to a one-time mifepristone dose that is used to end an early pregnancy.
 
P-glycoprotein (Pgp) Inducers
P-glycoprotein is a protein in the body that helps remove substances, such as medications, from the tissues in the body so they can be removed through the urine or feces. Pgp helps remove Toposar from the body. Certain medications known as Pgp inducers increase the activity of Pgp.
 
Combining Toposar with one of these Pgp inducers causes Toposar to be removed from the body too quickly, potentially making it less effective. If you use Toposar with a Pgp inducer, your healthcare provider may choose to monitor you more closely to make sure Toposar is working effectively.
 
P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a protein in the body that helps remove substances, such as medications, from the tissues in the body so they can be removed through the urine or feces. Pgp helps remove Toposar from the body. Certain medications known as Pgp inhibitors decrease the activity of Pgp.
 
Combining Toposar with one of these Pgp inhibitors causes Toposar to be removed more slowly, potentially increasing the amount of Toposar in your blood and increasing your risk for serious side effects. Your healthcare provider may choose to monitor you more closely for side effects if you use these medications together.
 
Pimozide
Toposar may increase blood levels of pimozide, which could increase your risk for pimozide side effects. Talk to your healthcare provider before using these medicines together.
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