Toposar Drug Interactions

Toposar Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Toposar is combined with any of the drugs listed above.
Amphotericin B
Combining Toposar with amphotericin B could increase your risk for amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and breathing problems. Your healthcare provider may choose to monitor you more closely if you use these medicines together.
Toposar may increase blood levels of aripiprazole, which could increase your risk for aripiprazole side effects. If you use these medicines together, make sure to tell your healthcare provider if you experience any potential side effects of aripiprazole. He or she may choose to adjust your dose.
Atovaquone may increase blood levels of Toposar, increasing your risk for side effects. It is recommended that atovaquone not be given for at least two days before or two days after Toposar to avoid the possibility of this interaction.
Biologic and Immunologic Medications
Combining Toposar with biologic and immunologic medications that suppress the immune system could increase your risk for potentially serious side effects, including low blood cell counts and infections. Toposar should not be used in combination with some biologics or immunologic medicines, while other combinations will require dosage adjustments or careful monitoring. Talk to your healthcare provider about this potential interaction if you are taking biologic or immunologic medicines.
Using clozapine and Toposar together may increase the risk of dangerously low white blood cells, thereby increasing your risk for potentially serious infections. Talk to your healthcare provider before taking clozapine during Toposar treatment. However, do not stop taking clozapine unless your healthcare provider specifically tells you to do so.
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