Drug Interactions With Paclitaxel

Paclitaxel Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when paclitaxel is combined with any of the drugs listed above.
 
Certain Antibiotics or Antifungals
Combining certain antibiotics or antifungals with paclitaxel may increase the level of paclitaxel in your blood, potentially increasing your risk of paclitaxel side effects. Talk to your healthcare provider before taking these medications together.
 
Certain Anticonvulsants
Taking certain anticonvulsants (seizure medications) with Taxol may decrease the level of Taxol in your blood, perhaps making it less effective. Talk to your healthcare provider before taking these medications together.
 
Gemfibrozil
Gemfibrozil may increase the level of paclitaxel in your blood, perhaps increasing your risk of side effects. Talk with your healthcare provider before taking these medications together.
 
Doxorubicin
It has been reported that paclitaxel may increase the level of doxorubicin in the bloodstream. Your healthcare provider should take this into account if you receive both medications. 
 
Live Vaccinations
Because chemotherapy medicines (including paclitaxel) can suppress the immune system, it is generally best to avoid live vaccinations while receiving chemotherapy.
 
Protease Inhibitors
Combining a protease inhibitor with paclitaxel may increase the level of paclitaxel in your blood, possibly increasing your risk of side effects. Talk to your healthcare provider before taking these medications together.
 
Rifamycin Antibiotics
Taking paclitaxel with rifamycin antibiotics can affect the level of paclitaxel in your blood. Talk to your healthcare provider before taking these medications together.
 
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