Navelbine Warnings and Precautions

There are situations when using Navelbine is not appropriate or safe, such as when people have extremely low levels of a certain type of white blood cell. Safety warnings and precautions with Navelbine should be reviewed with your healthcare provider prior to starting treatment to help avoid potentially serious complications, such as nerve damage, bone marrow depression, or drug interactions.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to receiving Navelbine® (vinorelbine) if you have:
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Kidney disease, such as kidney failure
  • Low white blood cells
  • Lung disease
  • Problems with constipation
  • Had prior chemotherapy or radiation treatment
  • Neuropathy (nerve damage)
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Navelbine

Some warnings and precautions to be aware of prior to receiving this medication include the following:
  • Like other chemotherapy medicines, Navelbine can cause significant side effects and, therefore, requires close monitoring and careful dosage adjustments. Navelbine should only be given under the supervision of a healthcare provider experienced in using chemotherapy medicine.
You will need blood tests prior to treatment, before each dose, and after treatment ends to monitor your blood cell counts. Make sure to keep all of your healthcare and laboratory appointments.
  • Navelbine has been reported to cause lung and breathing problems, which may need to be treated with oxygen or medicines. Let your healthcare provider know if you have any signs of lung problems, such as:
    • Shortness of breath
    • Coughing
    • Difficulty breathing. 
  • Navelbine can slow down the movement of food and liquids through your digestive tract, which could lead to severe constipation and blockage of the intestines. If not properly treated, these problems can cause part of the intestines to die or to tear. Your healthcare provider can give you certain medicines to help prevent or treat constipation from Navelbine. Be aware of your bowel habits during treatment, and let your healthcare provider know if you have:
    • Constipation
    • Infrequent or difficult bowel movements
    • Abdominal (stomach) pain.
  • People receiving this medicine may experience nerve damage, known medically as neuropathy. Neuropathy usually causes feelings of numbness, tingling, or burning in the hands or feet. Let your healthcare provider know if you have a history of neuropathy, as you will need to be monitored more closely for this potential side effect.
  • This medication can cause severe irritation if it comes into contact with the skin or eyes. Tell your healthcare provider right away if you experience stinging, burning, pain, redness, or swelling at your injection site, or if you believe the medicine may have accidentally gotten in your eye.
  • This medication should be used cautiously in people with liver disease.
  • Navelbine is a pregnancy Category D medication, which means it may harm an unborn child if used during pregnancy (see Navelbine and Pregnancy).
  • It is unknown whether Navelbine passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using the drug (see Navelbine and Breastfeeding).
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