Drug Interactions With Mechlorethamine

More Detail on Drug Interactions With Mechlorethamine

The following sections explain in detail the potentially negative interactions that can occur when mechlorethamine is combined with any of the drugs listed above.
 
Amphotericin B
Combining chemotherapy medicines, including mechlorethamine, with amphotericin B could increase the risk for potentially serious amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and breathing problems. Your healthcare provider may choose to monitor you more closely if you use these medicines together.
 
Biologic and Immunologic Medications
If you take certain biologic and immunologic medicines during mechlorethamine treatment, you could have an increased risk for potentially serious side effects, including infections and anemia. Mechlorethamine should not be used in combination with some biologic or immunologic medicines, while other combinations will require dosage adjustments or close monitoring. Talk to your healthcare provider about this potential interaction if you are taking biologic or immunologic medicines with mechlorethamine.
 
Clozapine
Using clozapine and mechlorethamine together may cause extremely low white blood cell counts, which would increase your risk for serious infections. Talk to your healthcare provider about this potential interaction if you take clozapine. Do not stop taking clozapine unless your healthcare provider specifically tells you to do so.
 
Echinacea
Echinacea could potentially decrease the effectiveness of mechlorethamine. Speak with your healthcare provider before taking echinacea during mechlorethamine treatment.
 
Live Vaccinations
People who are receiving chemotherapy are generally advised to avoid getting a live vaccine. This is because live vaccines contain live viruses or bacteria. Because mechlorethamine can decrease the body's immune response, you could become infected with the virus or bacteria used to make the vaccine. Also, live vaccines may be less effective in people using mechlorethamine. Talk to your healthcare provider before getting a vaccination during mechlorethamine treatment.
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