Lung Cancer Home > Xalkori Side Effects

Vision problems, nausea, and constipation are some of the most commonly reported side effects that occurred during clinical studies on Xalkori. While reactions such as these tend to be minor, there are some potentially serious problems that need to be treated. Notify your healthcare provider immediately if you are taking Xalkori and develop side effects such as fever, dark urine, or vision problems.

An Introduction to Xalkori Side Effects

Just like any medicine, Xalkori® (crizotinib) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Xalkori. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects With Xalkori

Xalkori has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
In these studies, the most common Xalkori side effects included:
  • Vision problems, including double vision, flashes of light, blurred vision, and "floaters" -- in up to 64 percent of people
  • Nausea -- up to 57 percent
  • Vomiting -- up to 45 percent
  • Constipation -- up to 38 percent
  • Swelling due to fluid retention (edema) -- up to 38 percent
  • Fatigue -- up to 31 percent
  • Decreased appetite -- up to 27 percent
  • Dizziness -- up to 24 percent
  • Burning, tingling, and numbing sensations of the skin -- up to 23 percent
  • Shortness of breath -- up to 22 percent
  • Coughing -- up to 21 percent
  • Heartburn or indigestion -- up to 20 percent.
Other common reactions, occurring in 4 to 20 percent of people, included:
  • Symptoms of the common cold, such as congestion, runny nose, and sore throat
  • Abdominal (stomach) pain
  • Rash
  • Increase in liver enzymes
  • Headaches
  • Changes in sense of taste
  • Chest pain
  • Fever
  • Insomnia
  • Mouth pain, sores, and inflammation
  • Joint pain
  • Back pain
  • Low heart rate
  • Low white blood cell counts.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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