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More Detail on Drug Interactions With Nicotine Lozenges

The following sections explain in detail the potentially negative reactions that can occur when a nicotine lozenge is combined with any of the drugs listed above.
If you take a benzodiazepine, you may experience more sedation and drowsiness from the benzodiazepine medication when you stop smoking. Your healthcare provider may need to decrease your benzodiazepine dose.
Beta Agonists
Your healthcare provider may need to adjust the dose of your beta agonist medication when you stop smoking, or when you start using nicotine lozenges. Talk to your healthcare provider about your plans for smoking cessation.
Beta Blockers
Beta blockers may be more effective at decreasing blood pressure and heart rate when you no longer smoke. Your healthcare provider may need to decrease the dose of your beta blocker after you quit smoking.
Cimetidine may increase the level of nicotine in your body. If you use nicotine lozenges, talk to your healthcare provider about an alternative to cimetidine. Similar medications, such as ranitidine (Zantac®), do not react with the nicotine lozenge.
When you stop smoking, your clozapine blood levels may increase. However, because it contains nicotine, the nicotine lozenge may decrease clozapine levels. Your healthcare provider may choose to monitor you more closely, or check your clozapine levels with a simple blood test, when you start using the nicotine lozenge.
Flecainide blood levels may increase when you quit smoking, which could increase your risk for flecainide side effects. Talk to your healthcare provider about this possible interaction. You may need a lower flecainide dose.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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