Lung Cancer Home > Mechlorethamine Side Effects

A number of side effects were reported in clinical studies on mechlorethamine, including some that are potentially dangerous. Seek medical treatment immediately if you are undergoing treatment with this chemotherapy drug and develop problems like severe vomiting, joint pain, or unexplained bleeding. Some of the most commonly reported reactions include nausea and low levels of various white and red blood cells.

An Introduction to Side Effects of Mechlorethamine

As with any chemotherapy medicine, mechlorethamine (Mustargen®) can cause side effects. In fact, most people will experience some type of reaction to this drug, and some side effects can be quite significant. Talk to your healthcare provider about ways to prevent or lessen reactions to this medicine.
 
(This article covers many, but not all, of the possible side effects with mechlorethamine. Your healthcare provider can discuss a more complete list with you.)
 

Serious Mechlorethamine Side Effects

Some side effects of mechlorethamine are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
 
  • Severe nausea, vomiting, or diarrhea
  • Signs of infection, such as:
 
    • Fever
    • Chills
    • Aches and pains
    • Sore throat
    • Cough
    • Painful urination
 
  • Signs of anemia, such as:
 
    • Unusual tiredness
    • Weakness
    • Pale skin
    • Shortness of breath
 
  • Any unusual bleeding or bruising
  • Black, tarry, or bloody stools
  • Blood in the urine, with or without painful urination
  • Bleeding gums
  • A painful or blistering rash
  • Tingling, burning, or painful feelings of the skin
  • Swelling, burning, stinging, pain, or leakage of fluid around your injection site (the site where you receive your dose)
  • Reduced hearing
  • Swelling, redness, or tenderness in one area on an arm or leg
  • Yellowing of the skin or whites of the eyes (jaundice)
  • Decreased or painful urination
  • Joint pain or stiffness
  • Signs of an allergic reaction, such as:
 
    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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