Lung Cancer Home > Mechlorethamine Dosage

Individual guidelines for dosing mechlorethamine will depend on weight, the type of cancer being treated, and how you respond to the drug, among other factors. Mechlorethamine is given as an intravenous injection or as an injection directly into a body cavity. It is administered by a healthcare provider in a hospital or other healthcare setting.

An Introduction to Your Dosage of Mechlorethamine

The dosage of mechlorethamine (Mustargen®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The type of cancer you have
  • Your overall health
  • Your weight
  • How you respond to and tolerate the medication
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Mechlorethamine Dosing Guidelines

The usual recommended dosage of mechlorethamine is 0.4 mg per kg body weight (about 0.18 mg per lb), given all at once on one day, or divided up over two to four days. However, the actual amount given can vary considerably from person to person, based on their particular situation.
Because mechlorethamine can lower the levels of white blood cells, red blood cells, and platelets in your body, your healthcare provider will monitor your blood cell counts after your dose. You may receive another mechlorethamine dose when blood cell counts return to normal, which could be as soon as three weeks after the previous dose.

General Information on Receiving Mechlorethamine

Some considerations to keep in mind during treatment with mechlorethamine include the following:
  • This medicine is usually given as an injection into a vein (an intravenous, or IV, injection), although it may also be given directly into body cavities (the lining of the lungs, heart, or abdomen).
  • You will receive your dose by a trained healthcare provider in a healthcare setting, such as a hospital or clinic.
  • Your healthcare provider may give you other medicines to help reduce some of the mechlorethamine side effects, such as nausea and vomiting.
  • Mechlorethamine can be irritating if it comes into contact with the skin. Tell your healthcare provider immediately if you have pain, redness, or swelling at the IV site (the site where the needle goes into your vein).
  • For this drug to work properly, it must be used as prescribed.
  • If you are unsure about anything related to your dosage, please talk with your healthcare provider or pharmacist.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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