Iressa Drug Interactions

Iressa Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Iressa is combined with any of the drugs listed above.
 
Amphotericin B
Taking Iressa with amphotericin B could increase your risk for amphotericin B side effects, such as low blood pressure (hypotension) and breathing problems. Your healthcare provider may choose to monitor you more closely if you take these medicines together. 
 
Aripiprazole
Iressa may increase the amount of aripiprazole in your body, which could increase your risk for aripiprazole side effects. If you take these medications together, let your healthcare provider know if you are experiencing any side effects.
 
CYP 2D6 Inhibitor Medications
The liver breaks down Iressa using enzymes known as CYP 2D6 enzymes, and some medications known as CYP 2D6 inhibitors can decrease the activity of these enzymes. Thus, combining Iressa with one of these drugs may increase the level of Iressa in your body, increasing your risk for side effects.
 
CYP 3A4 Inducer Medications
The liver breaks down Iressa using enzymes known as CYP 3A4 enzymes, and some medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining Iressa with one of these drugs may decrease the level of Iressa in your body, potentially making it less effective. Your healthcare provider may recommend a higher Iressa dose (Iressa 500 mg a day) if you take it with a CYP 3A4 inducer.  
 
CYP 3A4 Inhibitor Medications
The liver breaks down Iressa using enzymes known as CYP 3A4 enzymes, and some medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Iressa with one of these drugs may increase the level of Iressa in your body, increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely for side effects if you take Iressa with a CYP 3A4 inhibitor.  
 
Digoxin
Iressa may decrease the amount of digoxin absorbed into the body, potentially making digoxin less effective. This interaction is only thought to occur with digoxin tablets. Your healthcare provider may choose to monitor you more closely if you take these medicines together, and adjust your digoxin dose if needed.
 
H2 blockers
H2 blockers may decrease the amount of Iressa absorbed from the stomach into the body, which could decrease the effectiveness of Iressa. Talk to your healthcare provider before taking an H2 blocker during Iressa treatment.
 
Metoprolol
Iressa may increase blood levels of metoprolol, increasing the risk for metoprolol side effects. This interaction is more likely to occur at higher Iressa doses (500 mg a day), and is less of a concern with the usual recommended Iressa dose of 250 mg a day.
 
Proton Pump Inhibitors (PPIs)
PPIs may decrease the amount of Iressa absorbed from the stomach into the bloodstream. This could make Iressa less effective. Talk to your healthcare provider before taking a PPI during Iressa treatment.
 
Topotecan
Iressa may increase blood levels of topotecan, increasing the risk for side effects. Talk to your healthcare provider before taking these medicines together.
 
Vinorelbine
Combining Iressa with vinorelbine could cause abnormally low white blood cells, which would increase the risk for developing infections. If you take these medicines together, your healthcare provider may need to closely monitor your blood cell counts. 
 
Warfarin
Taking Iressa with warfarin may increase the risk for dangerous bleeding, such as internal bleeding. Your healthcare provider may need to monitor you more closely by regularly checking your prothrombin time ("protime" or PT) and international normalized ratio (INR), if you take these medicines together.
 
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