Drug Interactions With Doxorubicin
Doxorubicin Interactions ExplainedThe following sections explain in detail the potentially negative interactions that can occur when doxorubicin is combined with any of the drugs listed above.
Cyclophosphamide (Cytoxan, Neosar)
Taking cyclophosphamide with doxorubicin may increase your risk of side effects. Be sure to talk to your healthcare provider about the risks and benefits of using these medications together.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Combining cyclosporine with doxorubicin can increase the risk of dangerous side effects, including seizures and problems with bone marrow and blood cells. Talk to your healthcare provider about the risks and benefits of using these medications together.
There have been reports of dangerous side effects when cytarabine was used with doxorubicin. These side effects included very severe inflammation of the colon and bloody stools.
Because chemotherapy (including doxorubicin) can suppress the immune system, it is generally best to avoid live vaccinations while receiving chemotherapy.
Paclitaxel (Onxol, Taxol)
Taking paclitaxel with doxorubicin can increase your risk of side effects. Talk to your healthcare provider about the benefits and risks of using these medications together.
Phenobarbital may decrease the level of doxorubicin in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your doxorubicin dosage.
Phenytoin (Dilantin, Phenytek)
Doxorubicin may decrease the level of phenytoin in your blood, perhaps making it less effective. Your healthcare provider may need to monitor your phenytoin levels and adjust your phenytoin dosage as necessary.